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Dispatched to the influential Japanese port of Dejima in 1799, ambitious clerk Jacob de Zoet resolves to earn enough money to deserve his wealthy fiancée, an effort that is challenged by his relationship with the midwife daughter of a samurai.

In 1984, teenager Holly Sykes runs away from home in England. Almost 60 years later, we find her in the far west of Ireland, raising two young children as the world's climate collapses. In between, Holly's life is repeatedly intersected by a...

Follows incidents in the lives of people living in various times and places.

"From Joan of Arc to Queen Elizabeth I, to Harriet Tubman and Susan B. Anthony, to Sally Ride and Jennifer Aniston, history is full of women without children. Some chose to forgo reproduction in order to pursue intellectually satisfying work--a...